C 021 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3581
Potent CCR4 antagonist
Product Description
C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively).Product Specifications
Molecular Weight
540.57
Formula
C27H41N5O2.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride
CAS Number
1784252-84-1
PubChem ID
56972238
InChI Key
GKJKNYQUFAPLOQ-UHFFFAOYSA-N
SMILES
COC1=C(OC)C=C(N=C(N4CCC(N5CCCCC5)CC4)N=C2NC3CCCCCC3)C2=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.96 | 50 | |
| DMSO | 53.93 | 100 |
Preparing Stock Solutions
for C 021 dihydrochloride
The following data is based on the product molecular weight 540.57
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.85 mL | 9.25 mL | 18.50 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.70 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.85 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yokoyama Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 2009 PMID: 19081254
Product Specific Notices for C 021 dihydrochloride
For research use only
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