BzATP triethylammonium salt

Name: BzATP triethylammonium salt
Brand: Tocris Bioscience
SKU: 3312
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3312

(2)

Citations (16)

COA / SDS

Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist

Key Product Details

Description:	Photoaffinity label for ATPase; also P2X₇ agonist and P2X₁/P2Y₁ partial agonist
Chemical Name:	2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphate tri(triethylammonium) salt
Purity:	≥95% (HPLC)
Molecular Weight:	1018.97

View Full Technical Details for BzATP triethylammonium salt

Technical Data
Citations / Reviews (2)

Biological Activity for BzATP triethylammonium salt

BzATP triethylammonium salt is a prototypic P2X₇ receptor agonist (EC₅₀ values are 3.6, 7 and 285 μM for rat, human and mouse receptors respectively). Exhibits 5 - 10 fold greater potency than ATP. Exhibits partial agonist activity at P2X₁ (pEC₅₀ = 8.7) and P2Y₁ receptors and can be used as a photoaffinity label for ATPase.

This compound is a mixture of isomers.

Technical Data for BzATP triethylammonium salt

M. Wt	1018.97
Formula	C₂₄H₂₄N₅O₁₅P₃.C₁₈H₄₅N₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
PubChem ID	71308559
InChi Key	HVOVBTNCGADRTH-WBLDMZOZSA-N
Smiles	NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O)[C@H]3O)C=N2)=NC=N1.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.NC6=C7C(N([C@@H]8O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]8OC(C9=CC=C(C(C%10=CC=CC=C%10)=O)C=C9)=O)C=N7)=NC=N6.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BzATP triethylammonium salt

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 5mM)

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References for BzATP triethylammonium salt

References are publications that support the biological activity of the product.

Surprenant The cytolytic P_2Z receptor for extracellular ATP identified as a P_2X receptor (P2X₇). Science. 1996 PMID: 8614837
Young Amino acid residues in the P2X₇ receptor that mediate differential sensitivity fo ATP and BzATP. Mol.Pharmacol. 2007 PMID: 17032903
Zhong Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br.J.Pharmacol. 1998 PMID: 9831914
Michel Serum constituents can effect 2'- & 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X₇ receptors. Br.J.Pharmacol. 2001 PMID: 11264244
Williams and Coleman Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-Benzoyl)benzoyl adenosine 5'-triphosphate. J.Biol.Chem. 1982 PMID: 6460764