BzATP triethylammonium salt

Name: BzATP triethylammonium salt
Brand: Tocris Bioscience
SKU: 3312
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3312

(2)

Citations (17)

COA / SDS

Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist

100% Guarantee

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist

View all P2X Receptor Agonists »

Product Description

BzATP triethylammonium salt is a prototypic P2X₇ receptor agonist (EC₅₀ values are 3.6, 7 and 285 μM for rat, human and mouse receptors respectively). Exhibits 5 - 10 fold greater potency than ATP. Exhibits partial agonist activity at P2X₁ (pEC₅₀ = 8.7) and P2Y₁ receptors and can be used as a photoaffinity label for ATPase.

This compound is a mixture of isomers.

Product Specifications

Molecular Weight

1018.97

Formula

C₂₄H₂₄N₅O₁₅P₃.C₁₈H₄₅N₃

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphate tri(triethylammonium) salt

PubChem ID

71308559

InChI Key

HVOVBTNCGADRTH-WBLDMZOZSA-N

SMILES

NC1=C2C(N([C@@H]3O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](OC(C4=CC=C(C(C5=CC=CC=C5)=O)C=C4)=O)[C@H]3O)C=N2)=NC=N1.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC.NC6=C7C(N([C@@H]8O[C@H](COP(OP(OP(O)([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]8OC(C9=CC=C(C(C%10=CC=CC=C%10)=O)C=C9)=O)C=N7)=NC=N6.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 5mM)

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Surprenant The cytolytic P_2Z receptor for extracellular ATP identified as a P_2X receptor (P2X₇). Science. 1996 PMID: 8614837
Young Amino acid residues in the P2X₇ receptor that mediate differential sensitivity fo ATP and BzATP. Mol.Pharmacol. 2007 PMID: 17032903
Zhong Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br.J.Pharmacol. 1998 PMID: 9831914
Michel Serum constituents can effect 2'- & 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X₇ receptors. Br.J.Pharmacol. 2001 PMID: 11264244
Williams and Coleman Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-Benzoyl)benzoyl adenosine 5'-triphosphate. J.Biol.Chem. 1982 PMID: 6460764