Budesonide
Tocris Bioscience, part of Bio-Techne | Catalog # 2671
Synthetic glucocorticoid; anti-inflammatory and chemopreventive
Key Product Details
Description
Synthetic glucocorticoid; anti-inflammatory and chemopreventive
Product Description
Budesonide is a synthetic anti-inflammatory glucocorticoid that displays chemopreventive activity. Prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. Reverses DNA hypomethylation and modulates expression of cancer related genes.Product Specifications
Molecular Weight
430.53
Formula
C25H34O6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(11β,16α)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
CAS Number
51333-22-3
PubChem ID
5281004
InChI Key
VOVIALXJUBGFJZ-KWVAZRHASA-N
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H]5[C@](C(CO)=O)4OC(CCC)O5)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.05 | 100 | |
| Ethanol | 21.52 | 50 |
Preparing Stock Solutions
for Budesonide
The following data is based on the product molecular weight 430.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.61 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pereira Modulation by budes. of DNA methylation and mRNA expression in mouse lung tumors. Int.J.Cancer 2006 PMID: 17163412
- Wattenberg Chemoprevention of pulmonary carcinogenesis by aerosolized budes. in female A/J mice. Cancer Res. 2007 PMID: 9407956
- Spencer Budesonide. A review of its pharmacological properties and therapeutic efficacy in inflammatory bowel disease. Drugs 1995 PMID: 8586030
Product Specific Notices for Budesonide
For research use only
Loading...
Loading...