BTB1
Tocris Bioscience, part of Bio-Techne | Catalog # 5399
Selective and ATP-competitive Kif18A inhibitor
Key Product Details
Description
Selective and ATP-competitive Kif18A inhibitor
Product Description
BTB1 is a selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.Product Specifications
Molecular Weight
297.71
Formula
C12H8ClNO4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
CAS Number
86030-08-2
PubChem ID
291461
InChI Key
VZDUQPHKUBZMLW-UHFFFAOYSA-N
SMILES
ClC1=CC([N+]([O-])=O)=C(S(C2=CC=CC=C2)(=O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.77 | 100 | |
| Ethanol | 5.95 | 20 |
Preparing Stock Solutions
for BTB1
The following data is based on the product molecular weight 297.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.36 mL | 16.79 mL | 33.59 mL |
| 5 mM | 0.67 mL | 3.36 mL | 6.72 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.36 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Catarinella BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 2009 PMID: 19856362
- Braun Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 2014 PMID: 25402598
Product Specific Notices for BTB1
For research use only
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