BTB1

Name: BTB1
Brand: Tocris Bioscience
SKU: 5399

Tocris Bioscience, part of Bio-Techne | Catalog # 5399

COA / SDS

Selective and ATP-competitive Kif18A inhibitor

Key Product Details

Description:	Selective and ATP-competitive Kif18A inhibitor
Chemical Name:	4-Chloro-2-nitro-1-(phenylsulfonyl)benzene
Purity:	≥98% (HPLC)
Molecular Weight:	297.71

View Full Technical Details for BTB1

Technical Data
Citations

Biological Activity for BTB1

BTB1 is a selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC₅₀ = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.

Technical Data for BTB1

M. Wt	297.71
Formula	C₁₂H₈ClNO₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	86030-08-2
PubChem ID	291461
InChi Key	VZDUQPHKUBZMLW-UHFFFAOYSA-N
Smiles	ClC1=CC([N+]([O-])=O)=C(S(C2=CC=CC=C2)(=O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BTB1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.77	100
	ethanol	5.95	20

Preparing Stock Solutions for BTB1

The following data is based on the product molecular weight 297.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.36 mL	16.79 mL	33.59 mL
5 mM	0.67 mL	3.36 mL	6.72 mL
10 mM	0.34 mL	1.68 mL	3.36 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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Reconstitution Calculator

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References for BTB1

References are publications that support the biological activity of the product.

Catarinella BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 2009 PMID: 19856362
Braun Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 2014 PMID: 25402598