BSJ-Bump
Tocris Bioscience, part of Bio-Techne | Catalog # 6922
Negative control for BSJ-03-123 (Cat. No. 6921)
Discontinued Product
6922 has been discontinued.
View all Active Degrader Negative Controls products.
Key Product Details
Description
Negative control for BSJ-03-123 (Cat. No. 6921)
Product Description
BSJ-Bump is a negative control for BSJ-03-123 (Cat. No. 6921). Displays binding and no degradation of Cdk6 in vitro.Licensing Information
Sold under license from Dana-Farber Cancer InstituteProduct Specifications
Molecular Weight
951.05
Formula
C48H58N10O11
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-(2-(2-(2-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-2-((2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
CAS Number
2409918-48-3
SMILES
O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N5CCN(CC5)CCOCCOCCOCCNC(COC6=C(C7=CC=C6)C(N(C7=O)C8C(N(C)C(CC8)=O)=O)=O)=O)C=N4)=NC=C3C(C)=C1C(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 95.11 | 100 |
Preparing Stock Solutions
for BSJ-Bump
The following data is based on the product molecular weight 951.05
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.05 mL | 5.26 mL | 10.51 mL |
| 5 mM | 0.21 mL | 1.05 mL | 2.10 mL |
| 10 mM | 0.11 mL | 0.53 mL | 1.05 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brand Homolog-selective degradation as a strategy to probe the function of CDK6 in AML. Cell Chem.Biol. 2019 PMID: 30595531
Product Specific Notices for BSJ-Bump
For research use only
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