BRL 54443

Tocris Bioscience, part of Bio-Techne | Catalog # 1129

Potent 5-ht1E and 5-HT1F agonist
Discontinued Product
1129 has been discontinued. View all 5-HT1E Receptor Agonists products.

Key Product Details

Description

Potent 5-ht1E and 5-HT1F agonist

View all 5-HT1E Receptor Agonists »

Product Description

BRL 54443 is a potent 5-ht1E/1F receptor agonist (pEC50 values are 8.5 and 8.6 respectively). Displays > 30-fold selectivity over other 5-HT and dopamine receptors (pKi values are 8.7. 8.9, 7.2, 6.9, 7.2, 5.9, 7.0, 6.5, < 6, < 6, 6.3 and 6.2 for human 5-HT1E, 1F, 1A, 1B, 1D, 2A, 2B, 2C, 4, 7, D2 and D3 receptors respectively). Induces 5-HT2A receptor-mediated mouse aortic contraction in vitro (pEC50 = 6.52). Active in vivo.

Product Specifications

Molecular Weight

230.31

Formula

C14H18N2O

Storage

Desiccate at +4°C

Chemical Name

5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole

CAS Number

57477-39-1

PubChem ID

2438

InChI Key

WKNFADCGOAHBPG-UHFFFAOYSA-N

SMILES

CN1CCC(CC1)C1=CNC2=CC=C(O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50

Preparing Stock Solutions for BRL 54443

The following data is based on the product molecular weight 230.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.68 mL 43.42 mL 86.84 mL
2.5 mM 1.74 mL 8.68 mL 17.37 mL
5 mM 0.87 mL 4.34 mL 8.68 mL
25 mM 0.17 mL 0.87 mL 1.74 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BRL 54443

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BRL 54443

For research use only

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