BRL 50481

Name: BRL 50481
Brand: Tocris Bioscience
SKU: 2237

Tocris Bioscience, part of Bio-Techne | Catalog # 2237

Citations (17)

COA / SDS

Selective PDE7 inhibitor

Key Product Details

Description:	Selective PDE7 inhibitor
Chemical Name:	N,N,2-Trimethyl-5-nitro-benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	244.26

View Full Technical Details for BRL 50481

Technical Data
Citations

Biological Activity for BRL 50481

BRL 50481 is a selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (K_i = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.

Licensing Information

Sold with the permission of GlaxoSmithKline

Compound Libraries for BRL 50481

BRL 50481 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BRL 50481

M. Wt	244.26
Formula	C₉H₁₂N₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	433695-36-4
PubChem ID	2921148
InChi Key	IFIUFCJFLGCQPH-UHFFFAOYSA-N
Smiles	CN(C)S(=O)(=O)C1=C(C)C=CC(=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BRL 50481

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	24.43	100
	DMSO	24.43	100

Preparing Stock Solutions for BRL 50481

The following data is based on the product molecular weight 244.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.09 mL	20.47 mL	40.94 mL
5 mM	0.82 mL	4.09 mL	8.19 mL
10 mM	0.41 mL	2.05 mL	4.09 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

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References for BRL 50481

References are publications that support the biological activity of the product.

Smith Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8⁺ T-lymphocytes. Mol.Pharmacol. 2004 PMID: 15371556