BRD 4354

Tocris Bioscience, part of Bio-Techne | Catalog # 6010

HDAC5 and HDAC9 inhibitor
Discontinued Product
6010 has been discontinued. View all Class I Histone Deacetylases Inhibitors products.

Key Product Details

Description

HDAC5 and HDAC9 inhibitor

View all Class I Histone Deacetylases Inhibitors »

Product Description

BRD 4354 is a HDAC5 and HDAC9 inhibitor (IC50 values are 0.85 and 1.88 μM, respectively). Also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Exhibits >20-fold selectivity for HDAC5/9 over HDAC1/2/3.

Product Specifications

Molecular Weight

382.89

Formula

C21H23ClN4O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol

CAS Number

315698-07-8

PubChem ID

3516032

InChI Key

XAFSFXYJOJWLJD-UHFFFAOYSA-N

SMILES

CCN1CCN(C(C2=C(C3=C(C(Cl)=C2)C=CC=N3)O)C4=CN=CC=C4)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.66 20
Ethanol 19.14 50

Preparing Stock Solutions for BRD 4354

The following data is based on the product molecular weight 382.89

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.22 mL 26.12 mL 52.23 mL
2.5 mM 1.04 mL 5.22 mL 10.45 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
25 mM 0.10 mL 0.52 mL 1.04 mL

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

x
=
x

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for BRD 4354

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BRD 4354

For research use only

Privacy Policy
Cookie Policy
Site Map
© Copyright 2026 Bio-Techne. All Rights Reserved. All trademarks and registered trademarks are the property of Bio-Techne and its brands unless otherwise specified.