Bortezomib

Name: Bortezomib
Brand: Tocris Bioscience
SKU: 7282

Tocris Bioscience, part of Bio-Techne | Catalog # 7282

Citations (45)

COA / SDS

High affinity proteasome inhibitor

Key Product Details

Description:	High affinity proteasome inhibitor
Chemical Name:	B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Purity:	≥98% (HPLC)
Molecular Weight:	384.24

View Full Technical Details for Bortezomib

Technical Data
Citations

Biological Activity for Bortezomib

Bortezomib is a high affinity proteasome inhibitor (K_i = 0.6 nM). Inhibits growth of multiple myeloma (MM) cell lines (IC₅₀ values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines. Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs). Acts synergistically with dexamethasone (Cat. No. 1126). Also cytotoxic in MCF-7 breast cancer cell line (IC₅₀ = 50 nM).

Compound Libraries for Bortezomib

Bortezomib is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Bortezomib

M. Wt	384.24
Formula	C₁₉H₂₅BN₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	179324-69-7
PubChem ID	387447
InChi Key	GXJABQQUPOEUTA-RDJZCZTQSA-N
Smiles	CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C1=NC=CN=C1)B(O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bortezomib

	Solvent	Max Conc. mg/mL
Solubility
	DMSO	50
	ethanol	10

Preparing Stock Solutions for Bortezomib

The following data is based on the product molecular weight 384.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1.31 mM	1.99 mL	9.93 mL	19.87 mL
6.55 mM	0.40 mL	1.99 mL	3.97 mL
13.1 mM	0.20 mL	0.99 mL	1.99 mL
65.5 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for Bortezomib

References are publications that support the biological activity of the product.

Hideshima The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 2001 PMID: 11306489
Teicher The proteasome inhibitor PS-341 in cancer therapy. Clin.Cancer Res. 1999 PMID: 10499643