Bobcat339

Name: Bobcat339
Brand: Tocris Bioscience
SKU: 6977

Tocris Bioscience, part of Bio-Techne | Catalog # 6977

COA / SDS

Ten-eleven translocation methylcytosine dioxygenase (TET) inhibitor

Key Product Details

Description:	Ten-eleven translocation methylcytosine dioxygenase (TET) inhibitor
Chemical Name:	4-Amino-1-[1,1'-biphenyl]-3-yl-5-chloro-2(1H)-pyrimidinone
Purity:	≥98% (HPLC)
Molecular Weight:	297.74

View Full Technical Details for Bobcat339

Technical Data
Citations

Biological Activity for Bobcat339

Bobcat339 is a selective cytosine-based inhibitor of ten-eleven translocation methylcytosine dioxygenase (TET) (IC₅₀ values are 33 and 73 μM for TET1 and TET2, respectively). Bobcat339 reduces DNA 5-hydroxymethylcytosine (5hmC) levels in cells without inhibiting the DNA methyltransferase DNMT3a.

Technical Data for Bobcat339

M. Wt	297.74
Formula	C₁₆H₁₂ClN₃O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2280037-51-4
PubChem ID	138319673
InChi Key	QMGYGOOYCNTEQO-UHFFFAOYSA-N
Smiles	NC1=NC(N(C2=CC(C3=CC=CC=C3)=CC=C2)C=C1Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bobcat339

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.77	100
	ethanol	1.49	5

Preparing Stock Solutions for Bobcat339

The following data is based on the product molecular weight 297.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.36 mL	16.79 mL	33.59 mL
5 mM	0.67 mL	3.36 mL	6.72 mL
10 mM	0.34 mL	1.68 mL	3.36 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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References for Bobcat339

References are publications that support the biological activity of the product.

Blecua The DNA methylation landscape of hematological malignancies: an update. Mol.Oncol. 2020 PMID: 32526054
Chua Cytosine-based TET enzyme inhibitors. ACS Med.Chem.Lett. 2019 PMID: 30783500