BMS 986187
Tocris Bioscience, part of Bio-Techne | Catalog # 5983
Potent positive allosteric modulator of δ receptors
Key Product Details
Description
Potent positive allosteric modulator of δ receptors
Product Description
BMS 986187 is a potent δ-opioid receptor positive allosteric modulator (EC50 = 30 nM). Exhibits 100-fold selectivity for δ over μ-opioid receptor. Enhances affinity of [Leu5]-Enkephalin (Cat.No. 1889), SNC 80 (Cat.No. 0764) and TAN 67 (Cat.No. 0921) for the δ-opioid receptor.Product Specifications
Molecular Weight
470.61
Formula
C31H34O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3,4,5,6,7,9-Hexahydro-3,3,6,6-tetramethyl-9-[4-[(2-methylphenyl)methoxy]phenyl]-1H-xanthene-1,8(2H)-dione
CAS Number
684238-37-7
PubChem ID
17379334
InChI Key
UEKIYVKPQNKSDI-UHFFFAOYSA-N
SMILES
CC(C=CC=C1)=C1COC2=CC=C(C=C2)C3C4=C(CC(C)(C)CC4=O)OC5=C3C(CC(C)(C)C5)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.41 | 20 |
Preparing Stock Solutions
for BMS 986187
The following data is based on the product molecular weight 470.61
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.62 mL | 53.12 mL | 106.25 mL |
| 1 mM | 2.12 mL | 10.62 mL | 21.25 mL |
| 2 mM | 1.06 mL | 5.31 mL | 10.62 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shang Proposed mode of binding and action of positive allosteric modulators at opioid receptors. ACS Chem.Biol. 2016 PMID: 26841170
- Burford Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor. J.Med.Chem. 2015 PMID: 25901762
Product Specific Notices for BMS 986187
For research use only
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