BMS 961
Tocris Bioscience, part of Bio-Techne | Catalog # 3410
Selective RARγ agonist
Product Description
BMS 961 is a selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.Product Specifications
Molecular Weight
399.46
Formula
C23H26FNO4
Storage
Store at +4°C
Purity
≥95% (HPLC)
Chemical Name
3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid
CAS Number
185629-22-5
PubChem ID
2418
InChI Key
AANFHDFOMFRLLR-UHFFFAOYSA-N
SMILES
CC1(C)C2=C(C=CC(C(O)C(NC3=CC=C(C(O)=O)C=C3F)=O)=C2)C(C)(C)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.95 | 100 |
Preparing Stock Solutions
for BMS 961
The following data is based on the product molecular weight 399.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.52 mL | 25.03 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.01 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Taneja Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA
- Klaholz Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ. Proc.Natl.Acad.Sci.
- Abu-Abed Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α. J.Biol.Chem. 1998 PMID: 9442090
Product Specific Notices for BMS 961
For research use only
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