BMS 753
Tocris Bioscience, part of Bio-Techne | Catalog # 3505
RARα-selective agonist
Product Description
BMS 753 is a RARα-selective agonist (Ki = 2 nM).Product Specifications
Molecular Weight
351.40
Formula
C21H21NO4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid
CAS Number
215307-86-1
PubChem ID
9884820
InChI Key
KFBPBWUZXBYJDG-UHFFFAOYSA-N
SMILES
O=C1C(C)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C(C)1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.14 | 100 | |
| Ethanol | 17.57 | 50 |
Preparing Stock Solutions
for BMS 753
The following data is based on the product molecular weight 351.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.85 mL | 14.23 mL | 28.46 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Taneja Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 1996 PMID: 8650243
- Dilworth Ligand-dependent activation of transcription in vitro by retinoid acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo. Proc.Natl.Acad.Sci.USA 1999 PMID: 10051583
- Gehin Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 1999 PMID: 10421757
Product Specific Notices for BMS 753
For research use only
Loading...
Loading...