BMS 493

Name: BMS 493
Brand: Tocris Bioscience
SKU: 3509

Tocris Bioscience, part of Bio-Techne | Catalog # 3509

Citations (100)

COA / SDS

Pan-RAR inverse agonist

Key Product Details

Description:	Pan-RAR inverse agonist
Chemical Name:	4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	404.5

View Full Technical Details for BMS 493

Technical Data
Citations

Biological Activity for BMS 493

BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).

Technical Data for BMS 493

M. Wt	404.5
Formula	C₂₉H₂₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	215030-90-3
PubChem ID	9909190
InChi Key	YCADIXLLWMXYKW-CMDGGOBGSA-N
Smiles	CC1(C)CC=C(C#CC3=CC=CC=C3)C2=C1C=CC(/C=C/C4=CC=C(C(O)=O)C=C4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 493

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.45	100

Preparing Stock Solutions for BMS 493

The following data is based on the product molecular weight 404.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.72 mL
5 mM	0.49 mL	2.47 mL	4.94 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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Reconstitution Calculator

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References for BMS 493

References are publications that support the biological activity of the product.

Germain Differential action on coregulator interaction defines retinoid agonists and neutral antagonists. Chem.Biol. 2009 PMID: 19477412
Rinkevich Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi. PLoS Biology. 2007 PMID: 17341137