BMS 493
Tocris Bioscience, part of Bio-Techne | Catalog # 3509
Pan-RAR inverse agonist
Key Product Details
Description
Pan-RAR inverse agonist
Product Description
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Enhances nuclear corepressor (NCoR) interaction with RARs. Binding induces analogous conformational changes in all RAR types (RARα, RARβ and RARγ).Product Specifications
Molecular Weight
404.50
Formula
C29H24O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoic acid
CAS Number
215030-90-3
PubChem ID
9909190
InChI Key
YCADIXLLWMXYKW-CMDGGOBGSA-N
SMILES
CC1(C)CC=C(C#CC3=CC=CC=C3)C2=C1C=CC(/C=C/C4=CC=C(C(O)=O)C=C4)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.45 | 100 |
Preparing Stock Solutions
for BMS 493
The following data is based on the product molecular weight 404.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.36 mL | 24.72 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Germain Differential action on coregulator interaction defines retinoid agonists and neutral antagonists. Chem.Biol. 2009 PMID: 19477412
- Rinkevich Systemic bud induction and retinioic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi. PLoS Biology. 2007 PMID: 17341137
Product Specific Notices for BMS 493
For research use only
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