BMS 309403
Tocris Bioscience, part of Bio-Techne | Catalog # 5258
Potent and selective FABP4 inhibitor
Key Product Details
Description
Potent and selective FABP4 inhibitor
Product Description
BMS 309403 is a potent and selective fatty acid binding protein 4, adipocyte (FABP4) inhibitor (Ki values are <2, 250 and 350 nM for FABP4, FABP3 and FABP5 respectively). Decreases fatty acid uptake in adipocytes in vitro and reduces atherosclerotic lesion area in a mouse model of atherosclerosis. Reduces blood glucose levels and increases insulin sensitivity in a mouse model of obesity. Orally active.Product Specifications
Molecular Weight
474.55
Formula
C31H26N2O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid
CAS Number
300657-03-8
PubChem ID
16122583
InChI Key
SJRVJRYZAQYCEE-UHFFFAOYSA-N
SMILES
CCC1=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=NN1C2=CC=CC=C2C3=CC=CC(OCC(O)=O)=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.45 | 100 |
Preparing Stock Solutions
for BMS 309403
The following data is based on the product molecular weight 474.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.11 mL | 10.54 mL | 21.07 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.21 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.11 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sulsky Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg.Med.Chem.Lett. 2007 PMID: 17502136
- Lin BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase. PLoS ONE 2012 PMID: 22952994
- Furuhashi Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 2007 PMID: 17554340
Product Specific Notices for BMS 309403
For research use only
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