BMS 303141
Tocris Bioscience, part of Bio-Techne | Catalog # 4609
ATP citrate lyase inhibitor; orally bioavailable
Key Product Details
Description
ATP citrate lyase inhibitor; orally bioavailable
Product Description
BMS 303141 is an ATP citrate lyase (ACL) inhibitor (IC50 = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC50 = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia; reduces cell proliferation in HepG2 and Huh-7 cell lines and in PD-1 deficient lymphomas. Orally bioavailable.Product Specifications
Molecular Weight
424.30
Formula
C19H15Cl2NO4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
CAS Number
943962-47-8
PubChem ID
90488956
InChI Key
LIZVMVYXZWADCK-UHFFFAOYSA-N
SMILES
ClC1=CC(Cl)=C(O)C=C1S(NC2=C(C3=CC=CC=C3)C=CC(OC)=C2)(=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.24 | 10 | |
| Ethanol | 21.21 | 50 |
Preparing Stock Solutions
for BMS 303141
The following data is based on the product molecular weight 424.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.71 mL | 23.57 mL | 47.14 mL |
| 2.5 mM | 0.94 mL | 4.71 mL | 9.43 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.71 mL |
| 25 mM | 0.09 mL | 0.47 mL | 0.94 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ma A novel direct homogeneous assay for ATP citrate lyase. J.Lipid Res. 2009 PMID: 19286649
- Wartewig PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. Nat.Cancer 2023 PMID: 37723306
- Li 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg.Med.Chem.Lett. 2007 PMID: 17383874
Product Specific Notices for BMS 303141
For research use only
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