BMS 193885

Tocris Bioscience, part of Bio-Techne | Catalog # 3242

Potent, competitive NPY Y1 receptor antagonist
Discontinued Product
3242 has been discontinued. View all NPY Receptor Antagonists products.

Key Product Details

Description

Potent, competitive NPY Y1 receptor antagonist

View all NPY Receptor Antagonists »

Product Description

BMS 193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. Reduces food intake and body weight via central Y1 inhibition and is brain penetrant.

Product Specifications

Molecular Weight

680.79

Formula

C33H42N4O6.C3H6O3

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1,4-Dihydro-4-[3-[[[[3-[4-(3-methoxyphenyl)-1-piperidinyl]propyl]amino]carbonyl]amino]phenyl]-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-dimethyl ester L-Lactate

CAS Number

679839-66-8

PubChem ID

56972234

InChI Key

BYHJIPSVXAFCDI-WNQIDUERSA-N

SMILES

CC1=C(C(OC)=O)C(C2=CC(NC(NCCCN3CCC(C4=CC=CC(OC)=C4)CC3)=O)=CC=C2)C(C(OC)=O)=C(C)N1.C[C@H](O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 13.62 20
DMSO 68.08 100

Preparing Stock Solutions for BMS 193885

The following data is based on the product molecular weight 680.79

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.47 mL 7.34 mL 14.69 mL
5 mM 0.29 mL 1.47 mL 2.94 mL
10 mM 0.15 mL 0.73 mL 1.47 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for BMS 193885

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BMS 193885

For research use only

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