BL 1249

Tocris Bioscience, part of Bio-Techne | Catalog # 3797

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
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Key Product Details

Description

K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator

View all Two-P Potassium Channels Activators »

Product Description

BL 1249 is a K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel opener (EC50 values are 5.5 μM and 8 μM, respectively). Exhibits selectivity for bladder over vascular tissue in vitro and in vivo (EC50 values are 1.26 and 21.0 μM for cultured bladder and aortic tissues respectively).

Product Specifications

Molecular Weight

291.35

Formula

C17H17N5

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine

CAS Number

18200-13-0

PubChem ID

16078951

InChI Key

YYNRZIFBTOUICE-UHFFFAOYSA-N

SMILES

C1(NC3=CC=CC4=C3CCCC4)=CC=CC=C1C2=NN=NN2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.14 100
1eq. NaOH 29.14 100

Preparing Stock Solutions for BL 1249

The following data is based on the product molecular weight 291.35

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.16 mL 34.32 mL
5 mM 0.69 mL 3.43 mL 6.86 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

Calculators

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Reconstitution Calculator

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Product Documents for BL 1249

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BL 1249

For research use only

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