BIIE 0246 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 7377
Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo
Key Product Details
Description
Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo
Alternative Names
BIIE 0246 2HCl,BIIE0246 2HCl
Product Description
BIIE 0246 hydrochloride is a potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y2 receptor (IC50 = 15 nM). Displays > 650-fold selectivity for NPY Y2 over Y1, Y4 and Y5 receptors. Active in vivo.Product Specifications
Molecular Weight
968.98
Formula
C49H57N11O6.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide dihydrochloride
CAS Number
246146-31-6
InChI Key
UESZCTPNTRZXHQ-SICTUBFJSA-N
SMILES
O=C(C1=C2C=CC=C1)NC3=CC=CC=C3C2N(CC4)CCN4C(CC5(CCCC5)CC(N[C@@H](CCCNC(N)=N)C(NCCN6C(N(C7=CC=CC=C7)N(C8=CC=CC=C8)C6=O)=O)=O)=O)=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 96.9 | 100 |
Preparing Stock Solutions
for BIIE 0246 hydrochloride
The following data is based on the product molecular weight 968.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.03 mL | 5.16 mL | 10.32 mL |
| 5 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 10 mM | 0.10 mL | 0.52 mL | 1.03 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dumont BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y2 receptor antagonist. Br.J.Pharmacol. 2000 PMID: 10725255
- Malmstrom Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y2 receptor antagonist, in vivo. Br.J.Pharmacol. 2001 PMID: 11487518
- Doods BIIE0246: a selective and high affinity neuropeptide Y Y2 receptor antagonist. Eur.J.Pharmacol. 1999 PMID: 10611450
Product Specific Notices for BIIE 0246 hydrochloride
For research use only
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