BIBU 1361 dihydrochloride

Product Description

BIBU 1361 dihydrochloride is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC₅₀ = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC₅₀ = 290 nM) and is selective over a range of other related tyrosine kinases (IC₅₀ > 10 μM). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.

Solubility

Preparing Stock Solutions for BIBU 1361 dihydrochloride

The following data is based on the product molecular weight 516.87

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.93 mL	9.67 mL	19.35 mL
5 mM	0.39 mL	1.93 mL	3.87 mL
10 mM	0.19 mL	0.97 mL	1.93 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Solca Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 2004 PMID: 15199094