BIBN 4096

Tocris Bioscience, part of Bio-Techne | Catalog # 4561

Potent and selective CGRP antagonist
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Key Product Details

Description

Potent and selective CGRP antagonist

Alternative Names

Olcegepant

View all Calcitonin and Related Receptor Antagonists »

Product Description

BIBN 4096 is a potent and selective CGRP receptor antagonist (IC50 values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (Ki = 14.4 pM); exhibits no significant affinity for 75 other receptors. BIBN 4096 improves pain symptoms in a mouse migraine model.

Product Specifications

Molecular Weight

869.65

Formula

C38H47Br2N9O5

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine

CAS Number

204697-65-4

PubChem ID

6918509

InChI Key

ITIXDWVDFFXNEG-JHOUSYSJSA-N

SMILES

O=C(N[C@H](CC4=CC(Br)=C(O)C(Br)=C4)C(N[C@@H](CCCCN)C(N5CCN(C6=CC=NC=C6)CC5)=O)=O)N(CC3)CCC3N2CC1=CC=CC=C1NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
2eq.HCl 43.48 50
DMSO 43.48 50

Preparing Stock Solutions for BIBN 4096

The following data is based on the product molecular weight 869.65

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 2.30 mL 11.50 mL 23.00 mL
2.5 mM 0.46 mL 2.30 mL 4.60 mL
5 mM 0.23 mL 1.15 mL 2.30 mL
25 mM 0.05 mL 0.23 mL 0.46 mL

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Product Documents for BIBN 4096

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BIBN 4096

For research use only

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