Bexarotene is a potent and selective RXR agonist (EC₅₀ values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.

Product Specifications

Molecular Weight

348.48

Formula

C₂₄H₂₈O₂

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

CAS Number

153559-49-0

PubChem ID

82146

InChI Key

NAVMQTYZDKMPEU-UHFFFAOYSA-N

SMILES

CC(CCC(C)2C)(C)C1=C2C=C(C)C(C(C3=CC=C(C(O)=O)C=C3)=C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.85	100
	Ethanol	6.97	20 with gentle warming

Preparing Stock Solutions for Bexarotene

The following data is based on the product molecular weight 348.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.35 mL	28.70 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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Background References

References are publications that support the biological activity of the product.

Yen A selective retinoid X receptor agonist bexar. (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours. Br.J.Cancer 2006 PMID: 16495926
Nie Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 2017 PMID: 28099842
Boehm Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J.Med.Chem. 1994 PMID: 8071941

Bexarotene

Tocris Bioscience, part of Bio-Techne | Catalog # 5819

Key Product Details

Description

Alternative Names

View all Retinoid X Receptor Agonists »

Product Description