BAY-u 3405

Name: BAY-u 3405
Brand: Tocris Bioscience
SKU: 2732
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2732

(1)

Citations (3)

COA / SDS

Dual TP/DP2 (CRTH2) receptor antagonist

Key Product Details

Description:	Dual TP/DP₂ (CRTH2) receptor antagonist
Alternative Names:	Ramatroban
Chemical Name:	(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	416.47

View Full Technical Details for BAY-u 3405

Technical Data
Citations / Reviews (1)

Biological Activity for BAY-u 3405

BAY-u 3405 is a potent dual antagonist of TP/DP₂ (CRTH2) prostanoid receptors (K_i values are 4.3, 4.5 and > 10000 nM for hDP₂, hTP and hDP₁ receptors respectively). Suppresses PGD₂-induced migration of human eosinophils (IC₅₀ = 170 nM).

Technical Data for BAY-u 3405

M. Wt	416.47
Formula	C₂₁H₂₁FN₂O₄S
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	116649-85-5
PubChem ID	123879
InChi Key	LDXDSHIEDAPSSA-OAHLLOKOSA-N
Smiles	FC(C=C4)=CC=C4S(N[C@@H](C3)CCC2=C3C1=CC=CC=C1N2CCC(O)=O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY-u 3405

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.65	100
	ethanol	41.65	100

Preparing Stock Solutions for BAY-u 3405

The following data is based on the product molecular weight 416.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.40 mL	12.01 mL	24.01 mL
5 mM	0.48 mL	2.40 mL	4.80 mL
10 mM	0.24 mL	1.20 mL	2.40 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for BAY-u 3405

References are publications that support the biological activity of the product.

Ishizuka Ramatroban (BAY u3405): a novel dual antagonist of TXA₂ receptor and CRTh2, a newly identified prostaglandin D₂ receptor. Cardiovasc.Drug Rev. 2004 PMID: 15179446
Ulven and Kostenis Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J.Med.Chem. 2005 PMID: 15715457
Sundstrom Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. J.Pharmacol.Exp.Ther. 2003 PMID: 12954791