BAY 9835

Name: BAY 9835
Brand: Tocris Bioscience
SKU: 8826

Tocris Bioscience, part of Bio-Techne | Catalog # 8826

COA / SDS

Potent ADAMTS7 and ADAMTS12 inhibitor

Key Product Details

Description:	Potent ADAMTS7 and ADAMTS12 inhibitor
Chemical Name:	5,6-Difluoro-N-[[(4S)-4-(1-methyl-1H-pyrazol-5-yl)-2,5-dioxo-4-imidazolidinyl]methyl]-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	493.39

View Full Technical Details for BAY 9835

Technical Data
Citations

Biological Activity for BAY 9835

BAY 9835 is a potent ADAMTS7 and ADAMTS12 inhibitor (IC₅₀ values are 6 nM and 30 nM, respectively). BAY 9835 is selective over other metalloproteases (ADAMTS4, ADAMTS5, ADAM8, ADAM10, ADAM17, MMP2, MMP12, MMP14, MMP15). BAY 9835 is the first orally bioavailable ADAMTS7 inhibitor.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 9835 probe summary on the SGC website.

Technical Data for BAY 9835

M. Wt	493.39
Formula	C₂₂H₁₆F₅N₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3032487-31-0
PubChem ID	170836223
InChi Key	LPQXZOJIUVOCAL-NRFANRHFSA-N
Smiles	O=C(C1=C(C2=CC=C(C=C2)C(F)(F)F)C(F)=C(C=C1)F)NC[C@@]3(C4=CC=NN4C)NC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 9835

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.34	100

Preparing Stock Solutions for BAY 9835

The following data is based on the product molecular weight 493.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.03 mL	10.13 mL	20.27 mL
5 mM	0.41 mL	2.03 mL	4.05 mL
10 mM	0.20 mL	1.01 mL	2.03 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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References for BAY 9835

References are publications that support the biological activity of the product.

Meibom BAY-9835: Discovery of the first orally bioavailable ADAMTS7 inhibitor. J.Med.Chem. 2024 PMID: 38348661