BAY 876

Name: BAY 876
Brand: Tocris Bioscience
SKU: 6199

Tocris Bioscience, part of Bio-Techne | Catalog # 6199

Citations (15)

COA / SDS

Potent and selective GLUT1 inhibitor

Key Product Details

Description:	Potent and selective GLUT1 inhibitor
Chemical Name:	N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	496.42

View Full Technical Details for BAY 876

Technical Data
Citations

Biological Activity for BAY 876

BAY 876 is a potent and selective GLUT1 inhibitor (IC₅₀ = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC₅₀ values are 10.8, 1.67 and 0.29 μM, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo. This compound is cell permeable and orally bioavailable.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 876 is reviewed.

Technical Data for BAY 876

M. Wt	496.42
Formula	C₂₄H₁₆F₄N₆O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1799753-84-6
PubChem ID	118191391
InChi Key	BKLJDIJJOOQUFG-UHFFFAOYSA-N
Smiles	O=C(NC1=C(C)N(CC2=CC=C(C#N)C=C2)N=C1C(F)(F)F)C3=CC(C(N)=O)=NC4=C3C=CC(F)=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 876

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.64	100

Preparing Stock Solutions for BAY 876

The following data is based on the product molecular weight 496.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.07 mL	20.14 mL
5 mM	0.40 mL	2.01 mL	4.03 mL
10 mM	0.20 mL	1.01 mL	2.01 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for BAY 876

References are publications that support the biological activity of the product.

Ma Ovarian cancer relies on glucose transporter 1 to fuel glycolysis and growth: anti-tumor activity of BAY-876. Cancers (Basel) 2018 PMID: 30602670
Siebeneicher Identification and optimization of the first highly selective GLUT1 inhibitor BAY-876. ChemMedChem. 2016 PMID: 27552707