BAY 826
Tocris Bioscience, part of Bio-Techne | Catalog # 6579
Potent Tie2 inhibitor
Product Description
BAY 826 is a potent Tie 2 inhibitor (IC50 = 1.3 nM for autophosphorylation of Tie2 in HUVECs), which is selective for Tie2 over other angiogenic receptor tyrosine kinases, including VEGFR, FGFR and PDGFR. BAY 826 displays in vivo efficacy in some murine glioma models.Tie2 is also known as angiopoietin-1 receptor and TEK tyrosine kinase.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-826 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAY 826 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
558.53
Formula
C26H19F5N6OS
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
[3-Cyano-5-[[[2,4-dimethyl-5-[6-(3-pyridinyl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl]amino]carbonyl]phenyl]pentafluorosulfur
CAS Number
1448316-08-2
PubChem ID
71623052
InChI Key
MPASHPJAIUOWCK-UHFFFAOYSA-N
SMILES
CC1=CC(C)=C(C=C1N2C=CN3N=C(C4=CN=CC=C4)C=C23)NC(C5=CC(S(F)(F)(F)(F)F)=CC(C#N)=C5)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 | ||
| Ethanol | 100 |
Preparing Stock Solutions
for BAY 826
The following data is based on the product molecular weight 558.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.79 mL | 8.95 mL | 17.90 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.79 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schneider Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models. J.Neurochem. 2017 PMID: 27787897
Product Specific Notices for BAY 826
For research use only
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