BAY 8002
Tocris Bioscience, part of Bio-Techne | Catalog # 6817
Potent dual MCT1/2 inhibitor; orally bioavailable
Discontinued Product
6817 has been discontinued.
View all Monocarboxylate Transporter Inhibitors products.
Key Product Details
Description
Potent dual MCT1/2 inhibitor; orally bioavailable
Product Description
BAY 8002 is a potent dual MCT1/2 inhibitor (IC50 values are 3, 8, and 12 nM at rat (C6), human (DLD-1) and mouse (4T1) MCT1 respectively; IC50 values of human MCT1, MCT2, and MCT4 isoforms recombinantly expressed in X. laevis oocytes are 1, 5 and >500 nM, respectively); suppresses bidirectional lactate transport. Inhibits cellular SNARF-5 fluorescence change (IC50 = 85 nM) in MCT1-expressing DLD-1 cells. Arrests growth and increases intratumor lactate levels of Raji tumor xenografts in mice. Orally bioavailable.Product Specifications
Molecular Weight
415.85
Formula
C20H14ClNO5S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]benzoic acid
CAS Number
724440-27-1
PubChem ID
992293
InChI Key
CLAUJSRBKSRTGQ-UHFFFAOYSA-N
SMILES
OC(C1=C(C=CC=C1)NC(C2=C(C=CC(S(=O)(C3=CC=CC=C3)=O)=C2)Cl)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.58 | 100 |
Preparing Stock Solutions
for BAY 8002
The following data is based on the product molecular weight 415.85
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.40 mL | 12.02 mL | 24.05 mL |
| 5 mM | 0.48 mL | 2.40 mL | 4.81 mL |
| 10 mM | 0.24 mL | 1.20 mL | 2.40 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Quanz Preclinical efficacy of the novel monocarboxylate transporter 1 inhibitor BAY-8002 and associated markers of resistance. Mol.Cancer Ther. 2018 PMID: 30115664
Product Specific Notices for BAY 8002
For research use only
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