BAY 60-6583

Name: BAY 60-6583
Brand: Tocris Bioscience
SKU: 4472

Tocris Bioscience, part of Bio-Techne | Catalog # 4472

Citations (70)

COA / SDS

Potent partial A2B agonist; cardioprotective

Key Product Details

Description:	Potent partial A_2B agonist; cardioprotective
Chemical Name:	2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	379.44

View Full Technical Details for BAY 60-6583

Technical Data
Citations

Biological Activity for BAY 60-6583

BAY 60-6583 is a partial agonist at adenosine A_2B receptors (EC₅₀ = 2.83 nM for murine A_2B receptor). Displays selectivity for A_2B over A₁, A_2Aand A₃ receptors. BAY 60-6583 antagonizes the effect of NECA (Cat. No. 1691) and adenosine (Cat. No. 3624) in cAMP accumulation assays. Decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Cardioprotective; attenuates infarct size in a mouse model of myocardial ischemia. Exhibits ERK1/2-biased agonism.

Compound Libraries for BAY 60-6583

BAY 60-6583 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BAY 60-6583

M. Wt	379.44
Formula	C₁₉H₁₇N₅O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	910487-58-0
PubChem ID	11717831
InChi Key	ZTYHZMAZUWOXNC-UHFFFAOYSA-N
Smiles	NC1=NC(SCC(N)=O)=C(C#N)C(C2=CC=C(OCC3CC3)C=C2)=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 60-6583

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.94	100

Preparing Stock Solutions for BAY 60-6583

The following data is based on the product molecular weight 379.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.18 mL	26.35 mL
5 mM	0.53 mL	2.64 mL	5.27 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for BAY 60-6583

References are publications that support the biological activity of the product.

Hinz BAY60-6583 acts as a partial agonist at adenosine A_2B receptors. J.Pharmacol.Exp.Ther. 2014 PMID: 24633424
Gao Probing biased/partial agonism at the G protein-coupled A_2B adenosine receptor. Biochem. Pharmacol. 2014 PMID: 24853985
van der Hoeven A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils. J.Pharmacol.Exp.Ther. 2011 PMID: 21693629
Auchampach Characterization of the A_2B adenosine receptor from mouse, rabbit, and dog. J.Pharmacol.Exp.Ther. 2009 PMID: 19141710
Eckle Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation 2007 PMID: 17353435