Bay 55-9837

Name: Bay 55-9837
Brand: Tocris Bioscience
SKU: 2711

Tocris Bioscience, part of Bio-Techne | Catalog # 2711

Citations (12)

COA / SDS

Potent and selective VPAC2 agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective VPAC2 agonist

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Product Description

Bay 55-9837 is a selective VPAC₂ receptor agonist (EC₅₀ values are 0.4, 100 and >1000 nM for VPAC₂, VPAC₁ and PAC₁, respectively in a cAMP accumulation assay; IC₅₀ values are 60, 8700 and >10000 nM for VPAC₂, VPAC₁ and PAC₁, respectively in a competition binding assay). Stimulates glucose-dependent insulin secretion in isolated human pancreatic islets. Reduces HIV-1 viral replication and shows cooperative effects when given in conjunction with VPAC₁ agonists.

Product Specifications

Molecular Weight

3742.29

Formula

C₁₆₇H₂₇₀N₅₂O₄₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

463930-25-8

PubChem ID

72941824

InChI Key

NHMJBXFCQMBYCP-ZBLLYJRDSA-N

SMILES

[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Temerozo Macrophage resistance to HIV-1 infection is enhanced by the neuropeptides VIP and PACAP. PLoS ONE 2013 PMID: 23818986
Clairmont Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal. J.Med.Chem. 2006 PMID: 17149884
Pan Engineering novel VPAC2-selective agonists with improved stability and glucose-lowering activity in vivo. J.Pharmacol.Exp.Ther. 2007 PMID: 17110523
Tsutsumi A potent and highly selective VPAC2 agonist enhances glucose-induced Ins release and glucose disposal: a potential therapy for type 2 diabetes. Diabetes 2002 PMID: 11978642