BAY 390

Name: BAY 390
Brand: Tocris Bioscience
SKU: 7978

Tocris Bioscience, part of Bio-Techne | Catalog # 7978

COA / SDS

Potent and selective TRPA1 antagonist. Brain penetrant and orally bioavailable

Key Product Details

Description:	Potent and selective TRPA1 antagonist. Brain penetrant and orally bioavailable
Chemical Name:	(1R,2R)-2-[(4-Fluorophenyl)amino]-1-(trifluoromethyl)cyclohexanol
Purity:	≥98% (HPLC)
Molecular Weight:	277.26

View Full Technical Details for BAY 390

Technical Data
Citations

Biological Activity for BAY 390

BAY 390 is a potent and selective transient receptor potential ankyrin 1 (TRPA1) antagonist (IC₅₀ values are 16, 63 and 82 nM for hTRPA1 FLIPR, rTRPA1 FLIPR and hTRPA1 Ephys, respectively). In vivo, BAY 390 exhibits efficacy in rat models of inflammatory and neuropathic pain. BAY 390 is orally bioavailable and brain penetrant. Suitable to use as an in vitro or in vivo probe to investigate the roles of TRPA1 in models of acute, inflammatory, and neuropathic pain.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 390 probe summary on the SGC website.

Technical Data for BAY 390

M. Wt	277.26
Formula	C₁₃H₁₅F₄NO
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2741956-55-6
PubChem ID	155539293
InChi Key	IESAJAZKMLPVIB-VXGBXAGGSA-N
Smiles	FC(F)([C@]1(CCCC[C@H]1NC2=CC=C(F)C=C2)O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 390

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.73	100
	ethanol	27.73	100

Preparing Stock Solutions for BAY 390

The following data is based on the product molecular weight 277.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.61 mL	18.03 mL	36.07 mL
5 mM	0.72 mL	3.61 mL	7.21 mL
10 mM	0.36 mL	1.80 mL	3.61 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for BAY 390

References are publications that support the biological activity of the product.

Mesch Discovery of BAY-390, a selective CNS penetrant chemical probe as transient receptor potential ankyrin 1 (TRPA1) antagonist. J.Med.Chem. 2023 PMID: 36622903