BAY 091

Name: BAY 091
Brand: Tocris Bioscience
SKU: 7673

Tocris Bioscience, part of Bio-Techne | Catalog # 7673

COA / SDS

Potent and selective PIP4K2A inhibitor

Key Product Details

Description:	Potent and selective PIP4K2A inhibitor
Chemical Name:	(R)-2-((3-Cyano-2-(2'-fluoro-3'-methyl-[1,1'-biphenyl]-4-yl)-1,7-naphthyridin-4-yl)amino)butanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	440.48

View Full Technical Details for BAY 091

Technical Data
Citations

Biological Activity for BAY 091

BAY 091 is a potent and selective, ATP-dependent, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) inhibitor (IC₅₀ values are 1.3 nM, 8.5 nM and 16.4 nM with 10 μM ATP, or in an HTRF assay with 10 μM and 2 mM ATP, respectively).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 091 probe summary on the SGC website.

Technical Data for BAY 091

M. Wt	440.48
Formula	C₂₆H₂₁FN₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2922280-34-8
PubChem ID	155884467
InChi Key	DVIVLYHDLNAXAT-OAQYLSRUSA-N
Smiles	CC[C@H](C(O)=O)NC1=C(C(C2=CC=C(C3=C(C(C)=CC=C3)F)C=C2)=NC4=C1C=CN=C4)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 091

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.02	50 with gentle warming

Preparing Stock Solutions for BAY 091

The following data is based on the product molecular weight 440.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.54 mL	22.70 mL	45.41 mL
2.5 mM	0.91 mL	4.54 mL	9.08 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
25 mM	0.09 mL	0.45 mL	0.91 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for BAY 091

References are publications that support the biological activity of the product.

Wortmann Discovery and characterization of the potent and highly selective 1,7-naphthyridine-based inhibitors BAY-091 and BAY-297 of the kinase PIP4K2A. J.Med.Chem. 2021 PMID: 34699202