Baricitinib
Tocris Bioscience, part of Bio-Techne | Catalog # 7222
Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2
Key Product Details
Description
Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2
Alternative Names
INCB 28050
Product Description
Baricitinib is a highly potent JAK1 and JAK2 inhibitor (IC50 values are 5.9 and 5.7 nM, respectively). Also inhibits Tyk2 (IC50 = 53 nM). Displays >100-fold selectivity for JAK1/2 over JAK3 (IC50 = 53 nM for JAK3). Binds AAK1, BIKE, GAK and MPSK1 in vitro (Kd values are 17.2, 39.8, 134.4 and 68.5 nM, respectively). Inhibits IL-6-induced STAT phosphorylation and subsequent pro-inflammatory chemokine (MPC-1) and cytokine (IL-17 and IL-22) production in PBMCs and T-cells. Displays anti-inflammatory and disease modifying effects in the rat adjuvant arthritis model. In silico modelling predicts inhibition of SARS-CoV-2 cell entry.Product Specifications
Molecular Weight
371.42
Formula
C16H17N7O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
CAS Number
1187594-09-7
PubChem ID
44205240
InChI Key
XUZMWHLSFXCVMG-UHFFFAOYSA-N
SMILES
CCS(=O)(N1CC(C1)(N2C=C(C3=C4C=CNC4=NC=N3)C=N2)CC#N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.14 | 100 |
Preparing Stock Solutions
for Baricitinib
The following data is based on the product molecular weight 371.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.46 mL | 26.92 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.38 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sorrell Family-wide structural analysis of human numb-associated protein kinases. Structure. 2016 PMID: 26853940
- Richardson Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. Lancet. 2020 PMID: 32032529
- Fridman Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J.Immunol. 2010 PMID: 20363976
Product Specific Notices for Baricitinib
For research use only
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