B02

Tocris Bioscience, part of Bio-Techne | Catalog # 6392

RAD51 recombinase inhibitor
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Key Product Details

Description

RAD51 recombinase inhibitor

View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

B02 is a RAD51 recombinase inhibitor, exhibiting selectivity for human RAD51 over the E.coli homologue RecA (IC50 values are 27.4 μM and >250 μM, respectively). Inhibits homologous recombination and increases cellular sensitivity to DNA damage in vitro. Enhances the therapeutic effect of cisplatin (Cat. No. 2251) on tumor cells in vivo.

Product Specifications

Molecular Weight

339.40

Formula

C22H17N3O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

CAS Number

1290541-46-6

PubChem ID

5738263

InChI Key

GEKDQXSPTHHANP-OUKQBFOZSA-N

SMILES

O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=CC=CC=C41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.94 100
Ethanol 3.39 10

Preparing Stock Solutions for B02

The following data is based on the product molecular weight 339.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.46 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for B02

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for B02

For research use only

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