Azimilide dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6318

Kv11.1 (hERG) channel blocker
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Key Product Details

Description

Kv11.1 (hERG) channel blocker

View all Voltage-gated Potassium Channel Blockers »

Product Description

Azimilide dihydrochloride is a Kv11.1 (hERG) channel blocker, blocks rapidly activating and slowly activating components of delayed rectifier K+ currents (IC50 of 0.4 mM and 3 mM, respectively). Also inhibits Na+/Ca2+ exchanger in vitro. Shows inhibition of Na+ currents, L-type Ca2+ currents and other K+ currents at high concentrations.

Product Specifications

Molecular Weight

530.88

Formula

C23H28ClN5O3.2HCl

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride

CAS Number

149888-94-8

PubChem ID

6435819

InChI Key

HHPSICLSNHCSNZ-DSHYBBOZSA-N

SMILES

CN1CCN(CC1)CCCCN2C(CN(C2=O)/N=C/C3=CC=C(C4=CC=C(C=C4)Cl)O3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.54 50

Preparing Stock Solutions for Azimilide dihydrochloride

The following data is based on the product molecular weight 530.88

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.77 mL 18.84 mL 37.67 mL
2.5 mM 0.75 mL 3.77 mL 7.53 mL
5 mM 0.38 mL 1.88 mL 3.77 mL
25 mM 0.08 mL 0.38 mL 0.75 mL

Calculators

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Product Documents for Azimilide dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Azimilide dihydrochloride

For research use only

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