AZD 1208

Name: AZD 1208
Brand: Tocris Bioscience
SKU: 6310

Tocris Bioscience, part of Bio-Techne | Catalog # 6310

Citations (11)

COA / SDS

Potent pan Pim kinase inhibitor

Key Product Details

Description:	Potent pan Pim kinase inhibitor
Chemical Name:	(5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	379.48

View Full Technical Details for AZD 1208

Technical Data
Citations

Biological Activity for AZD 1208

AZD 1208 is a potent pan Pim kinase inhibitor (IC₅₀ values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. AZD 1208 downmodulates the expression of Mayaro virus (MAYV) structural protein E1 and non-structural protein 1 (nsP1), and it reduces MAYV replication in a dose-dependent manner in HeLa or HDFs cells. Chemosensitizer.

Technical Data for AZD 1208

M. Wt	379.48
Formula	C₂₁H₂₁N₃O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1204144-28-4
PubChem ID	58423153
InChi Key	MCUJKPPARUPFJM-UWCCDQBKSA-N
Smiles	N[C@@H]1CCCN(C2=C(C3=CC=CC=C3)C=CC=C2/C=C4SC(NC\4=O)=O)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 1208

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.59	20 with gentle warming

Preparing Stock Solutions for AZD 1208

The following data is based on the product molecular weight 379.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.18 mL	65.88 mL	131.76 mL
1 mM	2.64 mL	13.18 mL	26.35 mL
2 mM	1.32 mL	6.59 mL	13.18 mL
10 mM	0.26 mL	1.32 mL	2.64 mL

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References for AZD 1208

References are publications that support the biological activity of the product.

Salazar Targeting host PIM protein kinases reduces Mayaro virus replication. Viruses 2022 PMID: 35216015
Brasó-Maristany PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer. Nat.Med. 2016 PMID: 27775704
Dakin Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg.Med.Chem.Lett. 2012 PMID: 22727640
Keeton AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood 2014 PMID: 24363397