AZ'9567

Name: AZ'9567
Brand: Tocris Bioscience
SKU: 8897

Tocris Bioscience, part of Bio-Techne | Catalog # 8897

COA / SDS

Potent MAT2a (methionine adenosyltransferase 2a) inhibitor

Key Product Details

Description:	Potent MAT2a (methionine adenosyltransferase 2a) inhibitor
Chemical Name:	3-Cyclopropyl-4-[4-(difluoromethoxy)phenyl]-1,4-dihydro-6-(2-methyl-2H-indazol-5-yl)-5H-pyrazolo[4,3-b]pyridin-5-one
Purity:	≥98% (HPLC)
Molecular Weight:	447.45

View Full Technical Details for AZ'9567

Technical Data
Citations

Biological Activity for AZ'9567

AZ'9567 is a potent MAT2a (methionine adenosyltransferase 2a) inhibitor (IC₅₀ = 1.3 nM). AZ'9567 shows strong antiproliferative effect on methylthioadenosine phosphorylase (MTAP) null lymphoma, lung, and pancreatic cancer cell lines and in vivo in MTAP KO HCT116 xenograft mouse model (20 mg/kg twice a day). AZ'9567 is orally bioavailable.

Technical Data for AZ'9567

M. Wt	447.45
Formula	C₂₄H₁₉F₂N₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3056570-19-2
PubChem ID	170995115
InChi Key	QEASMQZYZCGOSA-UHFFFAOYSA-N
Smiles	O=C1C(C2=CC3=CN(C)N=C3C=C2)=CC4=C(N1C5=CC=C(C=C5)OC(F)F)C(C6CC6)=NN4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ'9567

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	44.74	100
	ethanol	4.47	10

Preparing Stock Solutions for AZ'9567

The following data is based on the product molecular weight 447.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.17 mL	22.35 mL
5 mM	0.45 mL	2.23 mL	4.47 mL
10 mM	0.22 mL	1.12 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for AZ'9567

References are publications that support the biological activity of the product.

Atkinson Development of a series of pyrrolopyridone MAT2A inhibitors. J.Med.Chem. 2024 PMID: 38466661