AZ 13705339
Tocris Bioscience, part of Bio-Techne | Catalog # 6177
Highly potent PAK1 and PAK2 inhibitor
Product Description
AZ 13705339 is a highly potent PAK1 and PAK2 inhibitor (IC50 values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC50 = 2.6 μM).Product Specifications
Molecular Weight
629.75
Formula
C33H36FN7O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile
CAS Number
2016806-57-6
PubChem ID
129909860
InChI Key
WPFLVPJXKWCRQK-UHFFFAOYSA-N
SMILES
CCS(=O)(C1=C(N2CCN(CC2)C)C=CC(NC3=NC=C(C(N(C4=CC(CO)=CC=C4C)CC5=C(C#N)C=CC=C5)=N3)F)=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 62.98 | 100 | |
| Ethanol | 12.6 | 20 with gentle warming |
Preparing Stock Solutions
for AZ 13705339
The following data is based on the product molecular weight 629.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.59 mL | 7.94 mL | 15.88 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 10 mM | 0.16 mL | 0.79 mL | 1.59 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- McCoull Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors. ACS Med.Chem.Lett. 2016 PMID: 27994749
Product Specific Notices for AZ 13705339
For research use only
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