Avasimibe

Name: Avasimibe
Brand: Tocris Bioscience
SKU: 6505

Tocris Bioscience, part of Bio-Techne | Catalog # 6505

COA / SDS

ACAT inhibitor

Key Product Details

Description:	ACAT inhibitor
Chemical Name:	2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate
Purity:	≥98% (HPLC)
Molecular Weight:	501.72

View Full Technical Details for Avasimibe

Technical Data
Citations

Biological Activity for Avasimibe

Avasimibe is an ACAT inhibitor (IC₅₀ = 3.3 μM). Inhibits cholesterol esterification and reduces plasma cholesterol levels in rats. Also inhibits tumor growth and prolongs survival time in a melanoma mouse model and reduces tumor growth and metastasis in a pancreatic cancer mouse model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Avasimibe

Avasimibe is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Avasimibe

M. Wt	501.72
Formula	C₂₉H₄₃NO₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	166518-60-1
PubChem ID	166558
InChi Key	PTQXTEKSNBVPQJ-UHFFFAOYSA-N
Smiles	CC(C1=CC(C(C)C)=C(C(C(C)C)=C1)CC(NS(=O)(OC2=C(C(C)C)C=CC=C2C(C)C)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Avasimibe

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.17	100
	ethanol	10.03	20

Preparing Stock Solutions for Avasimibe

The following data is based on the product molecular weight 501.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.97 mL	19.93 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Molarity Calculator

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Reconstitution Calculator

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References for Avasimibe

References are publications that support the biological activity of the product.

Yang Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature 2016 PMID: 26982734
Li Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. Oncogene 2016 PMID: 27132508
Lee Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets. J.Med.Chem. 1996 PMID: 8978833