Avasimibe

Tocris Bioscience, part of Bio-Techne | Catalog # 6505

ACAT inhibitor
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Key Product Details

Description

ACAT inhibitor

View all Acyl-CoA:Cholesterol Acyltransferase Inhibitors »

Product Description

Avasimibe is an ACAT inhibitor (IC50 = 3.3 μM). Inhibits cholesterol esterification and reduces plasma cholesterol levels in rats. Also inhibits tumor growth and prolongs survival time in a melanoma mouse model and reduces tumor growth and metastasis in a pancreatic cancer mouse model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

501.72

Formula

C29H43NO4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate

CAS Number

166518-60-1

PubChem ID

166558

InChI Key

PTQXTEKSNBVPQJ-UHFFFAOYSA-N

SMILES

CC(C1=CC(C(C)C)=C(C(C(C)C)=C1)CC(NS(=O)(OC2=C(C(C)C)C=CC=C2C(C)C)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.17 100
Ethanol 10.03 20

Preparing Stock Solutions for Avasimibe

The following data is based on the product molecular weight 501.72

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.93 mL
5 mM 0.40 mL 1.99 mL 3.99 mL
10 mM 0.20 mL 1.00 mL 1.99 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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Product Documents for Avasimibe

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Avasimibe

For research use only

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