Autophinib
Tocris Bioscience, part of Bio-Techne | Catalog # 6324
Potent VPS34 inhibitor
Product Description
Autophinib is a potent VPS34 (class III PI 3-kinase) inhibitor (IC50 = 19 nM). Inhibits starvation- and Rapamycin-induced autophagy (IC50 values = 40 and 90 nM, respectively).Product Specifications
Molecular Weight
346.73
Formula
C14H11ClN6O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
CAS Number
1644443-47-9
PubChem ID
129626605
InChI Key
CEUMAXLRGBKFQP-UHFFFAOYSA-N
SMILES
CC1=CC(NC2=NC(OC3=CC=C([N+]([O-])=O)C=C3)=NC(Cl)=C2)=NN1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.93 | 20 |
Preparing Stock Solutions
for Autophinib
The following data is based on the product molecular weight 346.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.42 mL | 72.10 mL | 144.20 mL |
| 1 mM | 2.88 mL | 14.42 mL | 28.84 mL |
| 2 mM | 1.44 mL | 7.21 mL | 14.42 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Robke Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. Angew.Chem.Int.Ed.Engl. 2017 PMID: 28544137
- Richters Identification and further development of potent TBK1 inhibitors. ACS Chem Biol. 2015 PMID: 25540906
Product Specific Notices for Autophinib
For research use only
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