AUTAC4
Tocris Bioscience, part of Bio-Techne | Catalog # 7699
Mitochondrial targeting AUTAC Degrader
Product Description
AUTAC4 is an autophagy-targeting chimera targeting mitochondria. Comprises p-fluorobenzyl guanine joined by a PEG linker to a 2-phenylindole-3-glyoxyaminde ligand for the translocator protein on the outer mitochondrial membrane. It delivers a guanine tag to the mitochondrial membrane and promotes mitophagy of damaged mitochondria. In Down syndrome cells, AUTAC4 degrades impaired mitochondria and promotes the generation of functionally normal mitochondria.Licensing Information
Sold under license from Tohoku Techno Arch.Product Specifications
Molecular Weight
869.97
Formula
C43H48FN9O8S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(16R)-16-[[[2-Amino-9-[(4-fluorophenyl)methyl]-6,9-dihydro-6-oxo-1H-purin-8-yl]thio]methyl]-15,18-dioxo-4,7,10-trioxa-14,17-diazanonadec-1-yl]-α-oxo-2-phenyl-1H-indole-3-acetamide
CAS Number
2267315-04-6
PubChem ID
137409907
InChI Key
IYRHHSZRPVKBSQ-XIFFEERXSA-N
SMILES
CC(N[C@H](C(NCCCOCCOCCOCCCNC(C(C1=C(C2=CC=CC=C2)NC3=CC=CC=C13)=O)=O)=O)CSC4=NC5=C(N4CC6=CC=C(C=C6)F)N=C(NC5=O)N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.4 | 20 |
Preparing Stock Solutions
for AUTAC4
The following data is based on the product molecular weight 869.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 5.75 mL | 28.74 mL | 57.47 mL |
| 1 mM | 1.15 mL | 5.75 mL | 11.49 mL |
| 2 mM | 0.57 mL | 2.87 mL | 5.75 mL |
| 10 mM | 0.11 mL | 0.57 mL | 1.15 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Takahashi AUTACs: cargo-specific degraders using selective autophagy. Mol.Cell. 2019 PMID: 31606272
Product Specific Notices for AUTAC4
For research use only
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