ATPA
Tocris Bioscience, part of Bio-Techne | Catalog # 1107
Potent and selective GluK1 kainate agonist
Key Product Details
Description
Potent and selective GluK1 kainate agonist
Product Description
ATPA is a selective and potent GluK1 (formerly GluR5) kainate receptor agonist (Ki = 4.3 nM), inactive at GluK6 (formerly GluR6) (Ki > 1 mM) and only weakly active at AMPA receptors (GluA1-4) and the kainate receptors GluK5 (formerly KA-2) and GluK3 (formerly GluR7) (Ki values of 6 - 14 μM).Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Product Specifications
Molecular Weight
228.25
Formula
C10H16N2O4
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
CAS Number
140158-50-5
PubChem ID
2253
InChI Key
PIXJURSCCVBKRF-UHFFFAOYSA-N
SMILES
CC(C)(C)C1=C(CC(N)C(O)=O)C(O)=NO1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.28 | 10 with gentle warming | |
| 1eq. NaOH | 4.57 | 20 with gentle warming |
Preparing Stock Solutions
for ATPA
The following data is based on the product molecular weight 228.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 21.91 mL | 109.53 mL | 219.06 mL |
| 1 mM | 4.38 mL | 21.91 mL | 43.81 mL |
| 2 mM | 2.19 mL | 10.95 mL | 21.91 mL |
| 10 mM | 0.44 mL | 2.19 mL | 4.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Matzen AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid. J.Med.Chem. 1997 PMID: 9046343
- Moldrich Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures. Eur.J.Pharmacol. 1999 PMID: 10478637
- Clarke A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 1997 PMID: 9335499
Product Specific Notices for ATPA
For research use only
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