ATN 161

Tocris Bioscience, part of Bio-Techne | Catalog # 6058

COA / SDS

α5β1 integrin receptor antagonist

Key Product Details

Description:	α5β1 integrin receptor antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	597.65

View Full Technical Details for ATN 161

Technical Data
Citations

Biological Activity for ATN 161

ATN 161 is a α5β1 integrin receptor antagonist. Reduces liver metastasis and improves survival in combination with 5-FU (Cat. No. 3257) in a mouse model of colon cancer. Reduces MLL tumor growth in rats and decreases tumor volume of human MDA-MB-231 cell xenografts in mice.

Technical Data for ATN 161

M. Wt	597.65
Formula	C₂₃H₃₅N₉O₈S
Single Letter Sequence	PHSCN (Modifications: Pro-1 = N-terminal Ac, Asn-5 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	262438-43-7
PubChem ID	9960285
InChi Key	MMHDBUJXLOFTLC-WOYTXXSLSA-N
Smiles	CC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ATN 161

Solubility

Soluble to 2mg/ml in water

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References for ATN 161

References are publications that support the biological activity of the product.

Khalili A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol.Cancer Ther. 2006 PMID: 16985061
Stoeltzing Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int.J.Cancer. 2003 PMID: 12584749
Livant Anti-invasive, antitumorigenic, and antimetastatic activities of the PHSCN sequence in prostate carcinoma. Cancer Res. 2000 PMID: 10667582