AS 19

Tocris Bioscience, part of Bio-Techne | Catalog # 1968

(1)

Citations (36)

COA / SDS

Potent 5-HT7 agonist

Key Product Details

Description:	Potent 5-HT₇ agonist
Chemical Name:	(2S)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin
Purity:	≥98% (HPLC)
Molecular Weight:	283.41

View Full Technical Details for AS 19

Technical Data
Citations / Reviews (1)

Biological Activity for AS 19

AS 19 is a potent 5-HT₇ receptor agonist (IC₅₀ = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo. AS 19 also promotes melanin synthesis in B16F10 murine melanoma cells.

Technical Data for AS 19

M. Wt	283.41
Formula	C₁₈H₂₅N₃
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	1000578-26-6
PubChem ID	23642275
InChi Key	BTTOYOKCLDAHHO-HNNXBMFYSA-N
Smiles	CC1=C(C2=CC=CC3=C2CC[C@H](N(C)C)C3)C(C)=NN1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AS 19

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	28.34	100
	DMSO	28.34	100

Preparing Stock Solutions for AS 19

The following data is based on the product molecular weight 283.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.53 mL	17.64 mL	35.28 mL
5 mM	0.71 mL	3.53 mL	7.06 mL
10 mM	0.35 mL	1.76 mL	3.53 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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Reconstitution Calculator

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References for AS 19

References are publications that support the biological activity of the product.

Tang Serotonin/5-HT₇ receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways. FASEB J. 2023 PMID: 36961387
Perez-Garcia An mRNA expression analysis of stimulation and blockade of 5-HT₇ receptors during memory consolidation. Behav.Brain Res. 2006 PMID: 16480781
Horiguchi The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. J.Pharmacol.Exp.Ther. 2011 PMID: 21558435
Perez-Garcia and Meneses Effects of the potential 5-HT₇ receptor agonist AS 19 in an autoshaping learning task. Behav.Brain Res. 2005 PMID: 15936093