Artemether
Tocris Bioscience, part of Bio-Techne | Catalog # 6818
Antimalarial; also inhibits neuroinflammation
Key Product Details
Description
Antimalarial; also inhibits neuroinflammation
Product Description
Artemether is an antimalarial. Prevents cerebral malaria in Plasmodium berghei infected mice. Exhibits synergistic effects with Methylene Blue (Cat. No. 3213) against P. falciparum in vitro. Inhibits neuroinflammation in neuronal/microglial cell co-cultures via induction of Nrf2 expression.Product Specifications
Molecular Weight
298.37
Formula
C16H26O5
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
CAS Number
71963-77-4
PubChem ID
68911
SMILES
[H][C@@]12CC[C@H]([C@@]3(CC[C@]4(OO[C@@]13[C@](O[C@@H]([C@@H]2C)OC)(O4)[H])C)[H])C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.84 | 100 | |
| Ethanol | 29.84 | 100 |
Preparing Stock Solutions
for Artemether
The following data is based on the product molecular weight 298.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.35 mL | 16.76 mL | 33.52 mL |
| 5 mM | 0.67 mL | 3.35 mL | 6.70 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.35 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Prada Upregulation of reactive oxygen and nitrogen intermediates in Plasmodium berghei infected mice after rescue therapy with chloroquine or artem. J.Antimicrob.Chemother. 1996 PMID: 8858461
- Akoachere In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins. Antimicrob.Agents Chemother. 2005 PMID: 16251300
- Okorji Antimalarial drug artem. inhibits neuroinflammation in BV2 microglia through Nrf2-dependent mechanisms. Mol.Neurobiol. 2015 PMID: 26607631
Product Specific Notices for Artemether
For research use only
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