ARL 17477 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3319
Selective nNOS inhibitor
Product Description
ARL 17477 dihydrochloride is a selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC50 values are 1 and 17 μM for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
442.83
Formula
C20H20ClN3S.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamide dihydrochloride
CAS Number
866914-87-6
PubChem ID
9824646
InChI Key
SOXBYIKSUDXMIE-UHFFFAOYSA-N
SMILES
ClC1=CC=CC(CNCCC2=CC=C(NC(C3=CC=CS3)=N)C=C2)=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.14 | 50 | |
| DMSO | 44.28 | 100 |
Preparing Stock Solutions
for ARL 17477 dihydrochloride
The following data is based on the product molecular weight 442.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.26 mL | 11.29 mL | 22.58 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.52 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.26 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- O'Neill ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res. 2000 PMID: 10899290
- Zhang ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J.Cereb.Flow Metab. 1996 PMID: 8964798
- Hicks Synergistic neuroprotective effects by combining an NMDA or AMPA receptor antagonist with nitric oxide synthase inhibitors in global cerebral ischaemia. Eur.J.Pharmacol. 1999 PMID: 10554878
Product Specific Notices for ARL 17477 dihydrochloride
For research use only
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