Aripiprazole
Tocris Bioscience, part of Bio-Techne | Catalog # 5584
High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
Key Product Details
Description
High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
Product Description
Aripiprazole is a high affinity dopamine D2 and 5-HT1A receptor partial agonist (Ki values are ~1.64 and 5.59 nM respectively). Also 5-HT2A antagonist (Ki = 8.7 nM). Suppresses morphine-induced emesis in vivo. Atypical antipsychotic.Product Specifications
Molecular Weight
448.39
Formula
C23H27Cl2N3O2
Storage
Store at -20°C
Purity
≥99% (HPLC)
Chemical Name
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
CAS Number
129722-12-9
PubChem ID
60795
InChI Key
CEUORZQYGODEFX-UHFFFAOYSA-N
SMILES
O=C2CCC1=CC=C(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)C=C1N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.84 | 100 |
Preparing Stock Solutions
for Aripiprazole
The following data is based on the product molecular weight 448.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.15 mL | 22.30 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shiokawa Usefulness of the DA system-stabilizer aripipr. for reducing morphine-induced emesis. Eur.J.Pharmacol. 2007 PMID: 17678644
- Davies Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 2004 PMID: 15592581
Product Specific Notices for Aripiprazole
For research use only
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