Arbidol
Tocris Bioscience, part of Bio-Techne | Catalog # 7235
Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
Key Product Details
Description
Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
Product Description
Arbidol is a broad spectrum antiviral. Displays activity against a range of respiratory and hepatitis viruses including influenza A, B and C, adenovirus, and hepatitis B and C. Increases stability of influenza viral hemagglutinins (HA) and prevents low-pH HA transition so inhibiting viral fusion. Also inhibits SARS-CoV-2 infection in vitro (IC50 = 4.11 μM).Product Specifications
Molecular Weight
513.88
Formula
C22H25BrN2O3S.HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl 6-Bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-1H-indole-3-carboxylate hydrochloride
CAS Number
131707-23-8
PubChem ID
9958103
InChI Key
OMZHXQXQJGCSKN-UHFFFAOYSA-N
SMILES
Cl.CCOC(=O)C1=C(CSC2=CC=CC=C2)N(C)C2=CC(Br)=C(O)C(CN(C)C)=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.39 | 100 | |
| Ethanol | 51.39 | 100 |
Preparing Stock Solutions
for Arbidol
The following data is based on the product molecular weight 513.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.73 mL | 19.46 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020 PMID: 32373347
- Boriskin Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr.Med.Chem. 2008 PMID: 18393857
Product Specific Notices for Arbidol
For research use only
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