Arachidonyl serotonin

Name: Arachidonyl serotonin
Brand: Tocris Bioscience
SKU: 2836

Tocris Bioscience, part of Bio-Techne | Catalog # 2836

COA / SDS

Dual FAAH inhibitor/TRPV1 antagonist

Discontinued Product

2836 has been discontinued. View all Additional Cannabinoid-related Compounds products.

Key Product Details

Description:	Dual FAAH inhibitor/TRPV1 antagonist
Alternative Names:	AA-5-HT
Chemical Name:	N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
Molecular Weight:	462.67

View Full Technical Details for Arachidonyl serotonin

Technical Data
Citations

Biological Activity for Arachidonyl serotonin

Arachidonyl serotonin is a dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC₅₀ values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA₂, CB₁ or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.

Technical Data for Arachidonyl serotonin

M. Wt	462.67
Formula	C₃₀H₄₂N₂O₂
Storage	Store at -20°C
CAS Number	187947-37-1
PubChem ID	10027372
InChi Key	QJDNHGXNNRLIGA-DOFZRALJSA-N
Smiles	O=C(NCCC1=CNC2=C1C=C(O)C=C2)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Arachidonyl serotonin

Solubility

Soluble Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

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References for Arachidonyl serotonin

References are publications that support the biological activity of the product.

Maione Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br.J.Pharmacol. 2007 PMID: 17279090
Bisogno Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem.Biophys.Res.Comms.
Di Marzo The endocannabinoid system and its therapeutic exploitation. Nat.Rev.Drug Discov. 2004 PMID: 15340387