AR-C 69931 tetrasodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 5720
Highly potent P2Y12 antagonist
Key Product Details
Description
Highly potent P2Y12 antagonist
Alternative Names
Cangrelor tetrasodium salt
Product Description
AR-C 69931 tetrasodium salt is a highly potent P2Y12 antagonist (IC50 = 0.4 nM). Inhibits ADP-induced human platelet aggregation ex vivo. Reduces thrombus weight and delays thrombus formation in a model of carotid artery thrombosis in vivo.Product Specifications
Molecular Weight
864.29
Formula
C17H21Cl2F3N5Na4O12P3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(Methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]adenosine-5'-O-(β,γ-dichloromethylene)triphosphate tetrasodium salt
CAS Number
163706-36-3
PubChem ID
10260031
InChI Key
COWWROCHWNGJHQ-OPKBHZIBSA-J
SMILES
O[C@@H]1[C@H](O)[C@@H](N2C3=NC(SCCC(F)(F)F)=NC(NCCSC)=C3N=C2)O[C@H]1COP(OP(C(Cl)(Cl)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 86.43 | 100 |
Preparing Stock Solutions
for AR-C 69931 tetrasodium salt
The following data is based on the product molecular weight 864.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.16 mL | 5.79 mL | 11.57 mL |
| 5 mM | 0.23 mL | 1.16 mL | 2.31 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.16 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ingall Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy. J.Med.Chem. 1999 PMID: 9925726
- Srinivasan The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels. J.Biol.Chem. 2009 PMID: 19346255
- Huang Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model. J.Pharmacol.Exp.Ther. 2000 PMID: 11046080
Product Specific Notices for AR-C 69931 tetrasodium salt
For research use only
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