AR-C 118925XX

Tocris Bioscience, part of Bio-Techne | Catalog # 4890

Selective and competitive P2Y2 antagonist
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Key Product Details

Description

Selective and competitive P2Y2 antagonist

View all P2Y Receptor Antagonists »

Product Description

AR-C 118925XX is a potent, selective, competitive and reversible P2Y2 receptor antagonist (pA2 = 8.43). Inactive against a panel of 37 other receptors at a concentration of 10 μM. AR-C 118925XX inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). Inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM).

Product Specifications

Molecular Weight

537.59

Formula

C28H23N7O3S

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

5-[[5-(2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl)-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-N-2H-tetrazol-5-yl-2-furancarboxamide

CAS Number

216657-60-2

PubChem ID

54210200

InChI Key

PVKNPGQAFNALOI-UHFFFAOYSA-N

SMILES

CC(C=C1)=CC2=C1C(C3=CN(CC4=CC=C(C(NC5=NN=NN5)=O)O4)C(NC3=S)=O)C(C=CC(C)=C6)=C6C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.76 100

Preparing Stock Solutions for AR-C 118925XX

The following data is based on the product molecular weight 537.59

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.86 mL 9.30 mL 18.60 mL
5 mM 0.37 mL 1.86 mL 3.72 mL
10 mM 0.19 mL 0.93 mL 1.86 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for AR-C 118925XX

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AR-C 118925XX

For research use only

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